北京师范大学化学学院
     
 

发布时间: 2016-11-23  浏览次数:

卢忠林

卢忠林 English

 

教授,博士生导师,理学博士(南京大学),博士后(德国, 瑞士, 加拿大)

通信地址:北京市新街口外大街19号 北京师范大学化学学院
邮编:100875
电话:010 5880 1804; 传真:010 5880 1804
电子邮箱: luzl@bnu.edu.cn
课题组主页:http://chem1.bnu.edu.cn/luzl

 

 

讲授课程

基础有机化学(双语)(专业基础课);生活化学实验及原理(优质通识课);
 

有机化学的魅力(新生研讨课);化学前沿与挑战(博士学位基础课负责人)
 

研究兴趣

1)生物有机化学:人工核酸酶, 非病毒基因载体, 生物探针和生物显像。
 

2)金属有机化学:磷酸酯和羧酸酯降解,金属钯环合成。
 

代表性论文

  1. Ding, A.-X.; Tang, Q.; Gao, Y.-G.; Shi, Y.-D.; Uzair, A.; Lu, Z.-L.*, [12]aneN3 Modified Tetraphenylethene Molecules as High-Performance Sensing, Condensing, and Delivering Agents toward DNAs. ACS Appl. Mater. Interfaces 2016, 8 (23), 14367-14378.
  2. Ding, A.-X.; Hao, H.-J.; Gao, Y.-G.; Shi, Y.-D.; Tang, Q.; Lu, Z.-L.*, D-A-D type chromophores with aggregation-induced emission and two-photon absorption: synthesis, optical characteristics and cell imaging. J. Mater. Chem. C 2016, 4 (23), 5379-5389.
  3. Gao, Y.-G.; Alam, U.; Tang, Q.; Shi, Y.-D.; Zhang, Y.; Wang, R.; Lu, Z.-L.*, Functional lipids based on [12]aneN3 and naphthalimide as efficient non-viral gene vectors. Org. Biomol. Chem. 2016, 14 (26), 6346-6354.
  4. Gao, Y.-G.; Tang, Q.; Shi, Y.-D.; Zhang, Y.; Wang, R.; Lu, Z.-L.*, A novel non-viral gene vector for hepatocyte-targeting and in situ monitoring of DNA delivery in single cells. RSC Adv. 2016, 6 (55), 50053-50060.
  5. Zhong, Y.-L.; Wang, Q.-H.; Yang, Y.; Lu, Z.-L.; He, L.; Gong, B., Hexakis(m-phenylene ethynylene) Macrocycles with Multiple H-Bonding Side Chains and Modified Cavities: Altered Stacking Strength and Persistent Tubular Assembly. Org. Lett. 2016, 18 (9), 2094-2097.
  6. Wei, X.; Zhang, G.; Shen, Y.; Zhong, Y.; Liu, R.; Yang, N.; Al-mkhaizim, F. Y.; Kline, M. A.; He, L.; Li, M.; Lu, Z.-L.*; Shao, Z.*; Gong, B.*, Persistent Organic Nanopores Amenable to Structural and Functional Tuning. J. Am. Chem. Soc. 2016, 138, 2749-2754.
  7. Gao Y. G., Shi Y. D., Zhang Y., Hu J., Lu Z. L.,* He L.* A naphthalimide-based [12]aneN3 compound as an effective and real-time fluorescence tracking nonvival gene vector. Chem. Commun., 2015, 51, 16695-16698.
  8. Yue P., Zhang Y., Guo Z. F., Cao A. C., Lu Z. L.* and Zhai Y. G. Synthesis of bifunctional molecules containing [12]aneN3 and coumarin moieties as effective DNA condensation agents and new non-viral gene vectors. Org. Biomol. Chem. 2015, 13, 4494-4505.
  9. Chen, H. L., Guo Z. F., Lu Z. L.* Controlling ion-sensing specificity of N-amidothioureas: From anion-selective sensors to highly Zn2+-selective sensors by tuning electronic effects. Org. Lett. 2012 14, 5070-5073.
  10. Li, Z. F.; Guo, Z. F.; Yan, H.; Lu, Z. L.*; Wu, D. Y.* Syntheses of [12]aneN3-oligopeptide conjugates as effective DNA condensation agents. Bioorg. Med. Chem.  2012, 20, 2897-2904.
  11. Yan, H.; Li, Z. F.; Guo, Z. F.; Lu, Z. L.*, Wang, F.; Wu, L. Z.* Effective and reversible DNA condensation induced by bifunctional molecules containing macrocyclic polyamines and naphthyl moieties, Bioorg. Med. Chem. 2012, 20, 801-808.
  12. Guo, Z. F.; Yan, H.; Li, Z. F.; Lu, Z. L.* Synthesis of mono- and di-[12]aneN3 ligands and study on the catalytic cleavage of RNA model 2-hydroxypropyl p-nitrophenyl phosphate with their metal complexes. Org. Biomol. Chem. 2011, 9, 6788-6796.
  13. Lu,Z. L.; Liu, T.; Neverov, A. A.; Brown, R. S.; Rapid three-step cleavage of RNA and DNA model systems promoted by a dinuclear Cu(II)-complex in Methanol. Energetic origins of the catalytic efficacy,  J. Am. Chem., Soc., 2007, 129, 11642-11652.
  14. Neverov, A. A.; Lu, Z. L.; Maxwell, C. I.; Mohamed, M. F.; White, C. J.; Tsang, J. S. W.; Brown, R. S.; Combination of a Dinuclear Zn2+ Complex and a Medium Effect Exerts a 1012-Fold Rate Enhancement of Cleavage of an RNA and DNA Model System. J. Am. Chem. Soc. 2006, 128,  16398-16405.
  15. Lu, Z. L.; Lindner E.; Mayer H. A. Applications of Sol-Gel Processed Interphase Catalysts. Chem. Rev. 2002, 102, 3543-3578.

     

 


 
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