Educational Background

1991 Dept. of Chemistry, Hubei University

1998 M.Sc., Dept. of Chemistry,Wuhan University

2001 Ph.D, Institute of Chemistry, Chinese Academy of Sciences

Professional Career

2013 Professor, College of Chemistry, Beijing Normal University, Director of Key Laboratory of Radiopharmaceuticals, Ministry of Education.

2006 Professor, Institute of Chemistry, Chinese Academy of Sciences

2004 Postdoctoral Research Associate-- Department of Chemistry & Biochemistry, University of Notre Dame, UAS

2001 Postdoctoral Research Associate, Institut Européen de Chimie et Biologie, Bordeaux, France

1991 Assistant engineer, Hubei University

Research Interest

We are dedicated to the design and construction of new self-assembled supramolecular systems that mimic the structure and function of biopolymers. We are particularly interested in supramolecular systems that: i) fold into well-defined conformation (foldamers) and ii) respond to external stimuli with well-defined positional displacements (synthetic molecular machines). We have so far exploited foldamers to solve problems in molecular recognition, transmembrane transport and asymmetric catalysis. As a part of the foldamer-based asymmetric catalysis research direction, we have also been studying how chemical composition of foldamers affects their helicity. Our work on synthetic molecular machines has focus on understanding how to control movements of submolecular components at the molecular level.

Awards

2012 Excellent tutor prize of Chinese Academy of Sciences,

2011 The National Science Fund for Distinguished Young Scholars,

2008 100-Talent Program,

2003 Excellent Poster Award--6th International Conference on Materials Chemistry, University of Sheffield, UK,

2001 Peng Yinggang Award of Chinese Academy of Sciences.

Recent Publications

78. A Visual Sensor Array for Pattern Recognition Analysis of Proteins Using Novel Blue-Emitting Fluorescent Gold Nanoclusters, Shenghao Xu, Xin Lu, Chenxi Yao, Fu Huang, Hua Jiang, Wenhao Hua, Na Na, Haiyan Liu, Jin Ouyang. Anal. Chem. 2014, 86, 11634？11639.

77. Self-Association of Aromatic Oligoamide Foldamers into Double Helices in Water, Jie Shang, Quan Gan, Simon J. Dawson, Fre？de？ric Rosu, Hua Jiang, Yann Ferrand, and Ivan Huc, Org. Lett. 2014, 16, 4992-4995. DOI: 10.1021/ol502259y

76. Preorganized Aryl-triazole Foldamers as Effective Transmembrane Transporters for Chloride Anion, Jie Shang, Wen Si, Wei Zhao, Yanke Che, Jun-Li Hou,* Hua Jiang*, Org. Lett. 2014, 16, 4008-4011. DOI: 10.1021/ol501772v

75. 王光霞，车延科，江华，旋转型单分子机器，化学进展，2014,26（6），909-918.

74. Qiaolian Li, Fu Huang, Yaxun Fan, Yilin Wang, Jianfeng Li, Yujian He*, Hua Jiang*, Ag(I)-directed Triple-stranded Helicates with meta-ethynylpyridine Ligands, Euro. J. Inorg. Chem. 2014, 3235-3244. DOI: 10.1002/ejic.201402345

73. Jie Shang, Nolan M. Gallagher, Fusheng Bie, Qiaolian Li, Yanke Che, Ying Wang,* Hua Jiang,* Aromatic Triazole Foldamers Induced by C–H？？？X (X = F, Cl) Intramolecular Hydrogen Bonding, J. Org. Chem. 2014, 79(11), 5134-5144. DOI: 10.1021/jo500582c.

72. Dongjian Zhu, Lin Xue, Guoping Li, Yanke Che, Hua Jiang*, A turn-on fluorescent probe for detection of hydrogen sulfide in aqueous solution and living cells, Org. Chem. Frontier, 2014, 1, 501-505.

71. 朱东建，江华*, 基于花菁的硫醇近红外比率荧光探针,影像科学与光化学， 2014，32（1），106-112.（封面）

70. Qing Liu, Lin Xue, Dong-Jian Zhu, Guo-Ping Li*, Hua Jiang*, Highly selective two-photon fluorescent probe for imaging of nitric oxide in living cells, Chin. Chem. Lett. 2014, 25, 19-23.(Cover)

69. Guoping Li, Dongjian Zhu, Lin Xue, * Hua Jiang*, Quinoline-based Fluorescent Probe for Ratiometric Imaging of Lysosomal pH, Org. Lett. 2013, 15(19), 5020-5023.

68. Fusheng Bie, Ying Wang, Jie Shang, Nolan M. Gallagher, and Hua Jiang*, Synergistic Recognition of Halide Anions and Saccharides by Oligohydrazide Foldamers, Euro. J. Org. Chem. 2013, 8135-8144.

67. Dongjian Zhu, Guoping Li, Lin Xue* and Hua Jiang*, Development of ratiometric near-infrared fluorescent probes using analyte-specific cleavage of carbamate. Org. Biorg. Chem. 2013, 28(11), 4577-4580.

66. Wei Yao, Yongli Yan, Lin Xue, Chuang Zhang, Guoping Li, Qingdong Zheng, Yong Sheng Zhao*, Hua Jiang*, and Jiannian Yao*, Controlling the Structures and Photonic Properties of Organic Nanomaterials via Molecular Design. Angew. Chem. Int. Ed. 2013, 52(33), 8713-8717. DOI: 10.1002/anie.201302894

65. Quan Gan, Ying Wang and Hua Jiang*, Twisted Helical Microfibers by Hierarchical Self-Assembly of an Aromatic Oligoamide Foldamer, Chin. J. Chem. 2013, 31, 651-656.

64. Qing Liu , Guoping Li, Dongjian Zhu, Lin Xue？, Hua Jiang ？, Design of Quinoline-based Fluorescent Probe for Ratiometric Detection of Cadmium in Aqueous Media, Chin. Chem. Lett. 2013, 24, 479-482.

63. Li, Guoping; Zhu, Dongjian; Liu, Qing; Xue, Lin*; Jiang, Hua*, A Strategy for Highly Selective Detecting and Imaging Hypochlorite Using Selenoxide Elimination, Org. Lett. 2013, 15 (8), 2002-2005.

62. Edward J. O’Neil, Hua Jiang, Bradley D. Smith*, Effect of bridging anions on the structure and stability of phenoxide bridged zinc dipicolylamine coordination complexes, Supramolecular Chemistry, 2013, 25, 315-322.

61. Guoping Li, Dongjian Zhu, Qing Liu, Lin Xue,* Hua Jiang*, Rapid Detection of Hydrogen Peroxide Based on Aggregation Induced Ratiometric Fluorescence Change, Org. Lett. 2013, 15 (4), 924–927.

60. Lin Xue，Guoping Li, Dongjian Zhu, Qing Liu, and Hua Jiang*，Rational Design of Ratiometric and Targetable Fluorescent Probe for Imaging Lysosomal Zinc Ions. Inorg. Chem. 2012, 51, 10842-10849. DOI: 10.1021/ic301307v.

59. Tao Pang, Jie Shang, Qin-Wan Yang, Yu Sun, An-Xin Wu,* and Hua Jiang*, An Unprecedented Triple Helix: Based on A Tetrameric Assembly of Macrocycle driven by weak C–H？？？π and C–H？？？O Interaction, CrystEngComm, 2012, 14, 5170–5173. DOI: 10.1039/C2CE25549A.

58. Quinoline-based fluorescent probe for ratiometric detection of hydrogen peroxide in aqueous solution, Yuan-Yu Qian,*, Lin Xue, Guo-Ping Li, Hua Jiang,* Dyes and Pigments, 2012, 95, 373-376.doi:10.1016/j.dyepig.2012.05.013.

57. Lisa Logie, Jean Harthill, Kashyap Patel, Sandra Bacon, D. Lee Hamilton, Katherine Macrae, Gordon McDougall, Huan-Huan Wang, Lin Xue, Hua Jiang, Kei Sakamoto, Alan R. Prescott, and Graham Rena*, Cellular Responses to the Metal-Binding Properties of Metformin, Diabetes, 2012, 61, 1423-1433. DOI: 10.2337/db11-0961.

56. Quan Gan, Jie Shang, Brice Kauffmann, Ying Wang, Fusheng Bie and Hua Jiang*, A highly stable double helix of aromatic oligoamide comprised of fused ring aromatic units, Tetrahedron, 2012, 68，4479-4484.

55. Lin Xue, Guoping Li, Cailan Yu, and Hua Jiang*, A Ratiometric and Targetable Fluorescent Sensor for Quantification of Mitochondrial Zinc Ions, Chem.-A Eur. J. 2012, 18, 1050-1054.

54. Ivan Huc* and Hua Jiang*, Organic Foldamers and Helices, chapter in Supramolecular Chemistry: From Molecules to Nanomaterials, Edited by J.W. Steed and P.A. Gale (eds). John Wiley & Sons Ltd, Chichester, UK, pp 2183-2206 (2012).

53. Fei Sun, Guanxin Zhang, Deqing Zhang,* Lin Xue, and Hua Jiang, Aqueous Fluorescence Turn-on Sensor for Zn2+ with a Tetraphenylethylene Compound, Org. Lett. 2011, 13(24), 6378-6381 (DOI: 10.1021/ol2026735).

52. 王颖，甘泉，江华*，阴离子协同组装折叠体，高等学校化学学报，2011,32(9), 1928-1938 （邀请综述）。 Ying Wang, Quan Gan, and Hua Jiang, Anions Mediated Foldamers, Chem. J. Chin. Univ., 2011,32(9), 1928-1938.

51. Huanhuan Wang, Lin Xue and Hua Jiang*, Ratiometric Fluorescent Sensor for Silver Ion and Its Resultant Complex for Iodide Anion in Aqueous Solution, Org. Lett. 2011, 13(15), 3844-3847. (DOI: 10.1021/ol2013632).

50. Yann Ferrand, Quan Gan, Brice Kauffmann, Hua Jiang* and Ivan Huc*, Template induced screw motions within an aromatic amide foldamer double helix, Angew. Chem. Int. Ed. 2011, 50, 7572 -7575. (DOI: 10.1002/anie.201101697).

49. Huan-Huan Wang, Lin Xue, Cai-Lan Yu, Yuan-Yu Qian* and Hua Jiang*, Rhodamine-based fluorescent sensor for mercury in buffer solution and living cells. Dyes and Pigments, 2011, 91, 350-355.

48. Lin Xue, Zhangjian Fang, Guoping Li , and Hua Jiang*, Highly sensitive fluorescent sensors for detection of zinc ion in aqueous solution and two-photon bioimaging, Sensors & Actuators: B. Chemical. 2011, 156, 410-415.

47. Lin Xue, Guoping Li, Qing Liu, Huanhuan Wang, Chun Liu, Xunlei Ding, Shenggui He* and Hua Jiang*, A Ratiometric Fluorescent Sensor Based on Inhibition of Resonance for Detecting Cadmium and Its Cellular Imaging, Inorg. Chem. 2011, 50, 3680-3690.

46. Q. Gan, Y. Wang, and H. Jiang*, Aromatic amide foldamers: A paradigm for structure-property relationships, Curr. Org. Chem. 2011, 15, 1293-1301.

45. Quan Gan, Yann Ferrand, Chunyan Bao, Brice Kauffmann, Axelle Grélard, Hua Jiang* and Ivan Huc*, Helix-Rod Host-Guest Complexes with Shuttling Rates Much Faster than Disassembly, Science, 2011, 331, 1172-1175.(Highlighted by Science, 2011, 331,This week in Science; Nature Chemistry, 2011, 3(5), 338; Chemical & Engineering News, March 7, 2011, 89(10), 42.)

44. Ying Wang, Junfeng Xiang, and Hua Jiang*, Halide-Guided Oligo(aryl-triazole-amide)s Foldamers: Receptors for Multiple Halide Ions, Chem.-A Eur. J. 2011, 17(2),613-619. 2010:

43. Wenpeng Zhang, Yue Wu, Ying Chen, Hua Jiang, Zilin Chen*，Simultaneous Separation of Four Metal Ions by CE Using Bis(2-Pyridylmethyl) (8-Pyridylmethyloxy-Quinoline-2-Methyl)Amine as Chelating Agent，Chromatographia, 2010, 72, 1201–1205。

42. Ying Wang, Fusheng Bie, and Hua Jiang*, Controlling Binding Affinities for Anions by a Photoswitchable Foldamer, Org. Lett. 2010, 12(16), 3630-3633.

41. Huan-Huan Wang, Lin Xue, Zhang-Jian Fang, Guo-Ping Li, Hua Jiang *, A colorimetric and fluorescent chemosensor for copper ions in aqueous media and its application in living cells, New J. Chem. 2010, 34,1239-1242. Highlights in Chemical Sciences, 2010, Volume 6, 3. Top 10 most accessed articles in New J. Chem from July to Octber, 2010.

40. H. Wang, L. Xue, Y. Qian*, and H. Jiang*, A novel ratiometric fluorescent sensor for silver ions, Org. Lett. 2010, 12(2), 292-295.

39. Quan Gan, Fei Li, Guoping Li, Brice Kauffmann, Junfeng Xiang, Ivan Huc* and Hua Jiang*, Heteromeric double helix formation by cross-hybridization of chloro– and fluoro–substituted quinoline oligoamides, ChemComm. 2010, 46 (2), 297-299.

38. Baohua Zhang, Tianhu Yuan, Hua Jiang*, Ming Lei*, Molecular dynamics simulations on the stability and assembly mechanisms of quadruple and double helical aromatic amide foldamers, J. Phys. Chem. B, 2009, 113 (31), 10934- 10941.

37. Lin Xue, Qing Liu and Hua Jiang*, Ratiometric Zn2+ Fluorescent Sensor and New Approach for Sensing Cd2+ by Ratiometric Displacement, Org. Lett. 2009, 11(15), 3454-3457.

36. Ying Weng; Fang Wang; Lin Xue; Zilin Chen, Hua Jiang, High Sensitive Determination of Zinc with Novel Water-soluble Small Molecular Fluorescent Sensor, Analytica Chimica Acta, 2009, 647 (2), 215-218.

35. Chunyan Bao, Quan Gan, Brice Kauffmann, Hua Jiang,* and Ivan Huc*，A self-assembled foldamer capsule: combining single and double helical segments in one aromatic amide sequence, Chem.-A Eur. J. 2009, 15 (43), 11530-11536.

34.Ying Wang, Fei Li, Yumiao Han, Fuyi Wang, and Hua Jiang*, Folding and Aggregation of Cationic Oligo(aryl-triazole)s in Aqueous Solution, Chem.-A Eur. J. 2009, 15 (37), 9424-9433.

33. F. Li, Q. Gan, L. Xue, Z.-M. Wang, and Hua Jiang*, H - bonding directed one-step synthesis of novel macrocyclic peptides from ε-aminoquinolinecarboxylic acid, Tetra. Lett., 2009,50 (20), 2367-2369.

32. X. Lin, C. Liu and H. Jiang*, A highly sensitive and selective fluorescent sensor for distinguishing cadmium from zinc ions in aqueous media, Org. Lett. 2009, 11(7), 1655-1658.

31. X. Lin, C. Liu and H. Jiang*, A ratiometric fluorescent sensor with a large Stokes shift for imaging zinc ion in living cell, Chem. Commun. 2009, 1061 - 1063.

30. C. Bao, B. Kauffmann, Q. Gan, K. Srinivas, Hua Jiang, and I. Huc, “Converting sequences of aromatic amino acid monomers into function: second generation helical capsules”, Angew. Chem. Int. Ed. 2008, 47, 4153-4156. Hot paper. Hightlighted by Nature Chemistry, DOI:10.1038/nchem.9.

29. L. Xue, H. Wang, X. Wang, and Hua Jiang*, “Modulating affinities of DPA-substituted quinoline sensors for zinc ions by varying pendant ligands”, Inorg. Chem. 2008, 47, 4310-4318.

28. Johnson, J. R.; Jiang, H.; Smith, B. D. “Zinc(II)-Coordinated Oligotyrosine: A New Class of Cell Penetrating Peptide” Bioconj. Chem. 2008, 19, 1033-1039. Cover paper.

27. W. M. Leevy, S. T. Gammon, J. R. Johnson, A. J. Lampkins, Hua Jiang, M. Marquez, D. Piwnica-Worms, M. A. Suckow, and B. D. Smith, “Noninvasive Optical Imaging of Staphylococcus aureus Bacterial Infection in Living Mice Using a Bis-Dipicolylamine-Zinc(II) Affinity Group Conjugated to a Near-Infrared Fluorophore” Bioconj. Chem. 2008, 686-692.

26. Q. Gan, C. Bao, B. Kauffmann, A. Grélard, J. Xiang, S. Liu, I. Huc*, and Hua Jiang* “Quadruple and double helices of 8-fluoroquinoline oligoamides” Angew. Chem. Int. Ed. 2008, 47, 1715-1718. Hot paper.

25. H. Wang, Q. Gan, X. Wang, L. Xue, S. Liu and Hua Jiang* “A Water-soluble, Small Molecular Fluorescent Sensor with Femtomolar Sensitivity for Zinc Ion.”Org. Lett. 2007, 9, 4995-4998.

24. D. Haldar, Hua Jiang, J.-M. Léger, I. Huc.“Double versus single helical structures of oligopyridine-dicarboxamide strands. Part 2: the role of side-chains” Tetrahedron, 2007, 63, 6322-6330.

23. W. M. Leevy, S. T. Gammon, Hua. Jiang, J. R. Johnson, D. J. Maxwell, E. N. Jackson, M. Marquez, D. Piwnica-Worms, B. D. Smith. “Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe” J. Am. Chem. Soc. 2006, 128, 16476-16477.

22．D. Haldar, Hua Jiang, J.-M. Léger, and I. Huc . Interstrand side chain – side chain interactions in a double helical foldamer. Angew. Chem. Int. Ed. 2006, 5483-5486.

21. Hua Jiang, B. D. Smith. “Dynamic molecular recognition on the surface of vesicle membrane.”Chem. Comm. 2006, 1407-1409.

20. C. Dolain, Hua Jiang, J.Léger, P. Guionneau, and I. Huc. “Chiral Induction in Quinoline-Derived Oligoamide Foldamers: Assignment of Helical Handedness and Role of Steric Effects.”J. Am. Chem. Soc. 2005, 127, 12943-12951.

19. C. Dolain, A. Grélard, M. Laguerre, Hua Jiang, V. Maurizot, I. Huc. Solution Structure of Quinoline- and Pyridine-Derived Oligoamide Foldamers. Chem. Eur. J. 2005, 11, 6135-6144.

18. Hua Jiang, E. O’Neil, K. DiVittorio, B. Smith. “Anion-Mediated Phase Transfer of Zinc(II)-Coordinated Tyrosine Derivatives.”Org. Lett. 2005, 3013-3016.

17. J. Mahoney, K. Stucker, Hua Jiang, I. Carmichael, N. R. Brinkmann, A. M. Beatty, B. C. Noll, B. D. Smith, “Molecular Recognition of Trigonal Oxyanions Using a Ditopic Salt Receptor: Evidence for Anisotropic Shielding Surface around Nitrate Anion.”J. Am. Chem. Soc. 2005, 127, 2922-2928.

16. R. Hanshaw, S. Hilkert, Hua Jiang, and B. D. Smith. “An Indicator Displacement System for Fluorescent Detection of Phosphate Oxyanions under Physiological Conditions”Tetra. Lett. 2004, 45(47), 8721-8724.

15. Hua Jiang, J-M Léger, P. Guionneau, and I. Huc. “Strained Aromatic Oligoamide Macrocycles as New Molecular Clips.”Org. Lett. 2004, 6, 2985.

14. Hua Jiang, V. Maurizot and I. Huc. “Double versus single helical structures of oligopyridine-dicarboxamide strands. Part 1: Effect of Oligomer Length.”Tetrahedron. 2004, 60, 10029-10038.

13. Hua Jiang, C. Dolain, J. Léger, H. Gornitzka, I. Huc, “Switching of Chiral Induction in Helical Aromatic Oligoamides Using Solid State-Solution State Equilibrium.”J. Am. Chem. Soc. 2004, 126, 1034-1035.

12. Hua Jiang, J. Léger, C. Dolain, P. Guionneau, and I. Huc. “Aromatic ？ -peptides: design, synthesis and structural studies of helical quinoline-derived oligoamide foldamers.”Tetrahedron, 2003, 59, 8365-8374.

11. Hua Jiang, J. Léger, I. Huc, “Aromatic ？ Peptides.”J. Am. Chem. Soc. 2003, 125, 3448-3449.

10. Hua Jiang and H. Xu, Wuli Huaxue Xuebao, 2001, 17(2), 1092-1096. (Chinese) 江华，许慧君，用能量转移探测萘－蒽二元体系的构象变化，物理化学学报，2001, 17(2), 1092-1096.

9. Hua Jiang and H. Xu. “Intramolecular exciplex and cation-mediated charge-transfer fluorescence in a podand carrying terminal electron donor and acceptor groups.” J. Chem. Soc. Perkin Trans. 2. 2001, 8. 1274-1279.

8. Hua Jiang, C. Niu and L. Chen. “Synthesis and Crystal Structure of 13-Phenyl-1,10-dithia-4,7-dioxa-13-aza-15-Crown-5”Chinese J. Structural Chemistry. 2001, 20(2), 83-87.

7. Hua Jiang, H. Xu and J. Ye, “Synthesis and cation-mediated electron transfer in intramolecular fluorescence quenching of donor–acceptor podands: observation of Marcus inverted region in forward electron transfer reactions.”J. Chem. Soc. Perkin Trans. 2. 2000, 5, 925-930.

6. Hua Jiang and H. Xu, “Synthesis and cation-mediated electron transfer in fluorescence quenching of donor-acceptor podands”, Chinese Chemical Letters, 2000, 11(9), 767-770.

5. Hua Jiang, H. Xu, S. Shen and Q. Zhou, Photographic Science and Photochemistry, 2000,18(3), 223-228.(Chinese). 江华，许慧君，沈淑引，周庆复，蒽醌冠醚铕离子络合物分子内能量转移，感光科学与光化学, 2000,18(3), 223-228.

4. H. Xu, X. LI, Hua Jiang and Q. Zhou, “Effect of Host-guest interactions on the photophysical properties of a monocrown ether substituted phthalocyanine”, Materials Science and Engineering (C), 1999, 10, 71-74.

3. Hua Jiang and H. Xu, P. Xia, Q. Zhou, “Synthesis and effect of cation binding on photophysical properties of 1,8-anthraceno-18-crown-5”, Chinese Chemical Letters, 1999, 10(12), 1015-1018.

2. C. Niu, Hua Jiang and C. Wu, “Synthesis and crystal structure of 10-phenyl-1,7-dithia-4-oxa-10-aza-12-crown-4”, Chemical Research in Chinese Universities, 1998, 14(4), 375-378.

1. C. Niu, Hua Jiang and C. Wu. “Synthesis of Two New Types of N-Phenyl and N, N’-Diphenyl Azathiacrown Ether Analogs”, Chinese Chemical Letters, 1998, 9(1), 17-20.