讲授课程

基础有机化学（双语）（专业基础课）；有机化学B（生物专业），有机化学II（化学专业）；有机化学的魅力（新生研讨课）；化学前沿与挑战（博士学位基础课）；合成化学（硕士生专业基础课）

研究兴趣

1）化学生物学：有机小分子非病毒基因载体和荧光探针的设计合成及性能研究；药物缓释体系的设计及性能研究；生物活性小分子荧光探针设计合成及性能研究。

2）超分子化学：分子拉链的设计合成及肽的折叠组装研究；刚性大环的设计合成及其可控自组装。

3）应用开发：工业废水处理，药物中间体研制。

4）科学教育、化学教育和师范生的书院制培养

代表性论文

(1) Li L.-T.; Liang Y.-X.; Yin P.-P.; Lai Y.-H.; Mai J.-W.; Wang Y.-R.; He J.-Y.; Su Z.-N.; Bai J.-Y.; Li W.-J.; Lu Z.-L.*; Dou D.*, Lipid nanocomposites for precisely triggered Ttc3 gene silencing in pulmonary fibrosis treatment, J. Control. Release, 2026, 393, 114780.

(2) Zhang X.; Zhao W.-J.; Han X.-Y.; Ren Z.-X.; Tang Q.*; Liu R.*; Lu Z.-L.*, Spatiotemporally Cascade-Releasing Polyester Nanoparticles for Synergistic Photodynamic/Chemo/Gene Therapy of Colorectal Cancer.Adv. Healthcare Mater., 2026, e00013.

(3) Sun W.; Wang .X.-F.; Yang F.; Tong M.-Q.; Dong R.-Q.; He C.-B.; Wang J.-E.; Zhu C.; Zhao Y.-W.; Lu Z.-L.*, Fluorescence and photothermal dual-modal image guided integrated diagnosis and treatment, Colloid.Surface B, 2025, 254, 114828.

(4) Zhang X.; Xu D.-Z.; Zhao W.-J.; Han X.-Y.; Lu Z.-L.*; Liu R.*, A Multifunctional Polyester Nanoplatform for the Synergistic Anticancer: Enhanced Photodynamic Therapy and Targeted Gene Silencing. Angew. Chem., Int. Ed., 2025, 62, e202303242.

(5) Xu D.-Z.; Yang J.-B.; Zhang X.; Ren Z.-X.; Liu R.; Tang Q.*; Lu Z.-L.*; Liu Y.*, Hybride nanoparticles composed of SN38-modified [12]aneN₃ and biotinylated lipids for targeted and synergistic lung Cancer therapy. Bioorg. Chem., 2025, 16, 108411.

(6) Yang J.-B.; Xu D.-Z.; Zhang Z.-H.; Zhang X.; Ren Z.-X.; Liu R.*; Lu Z.-L.*; Liu Y.*, Multifunctional System with Camptothecin and [12]aneN₃ Units for Effective In Vivo Anti Pancreatic Cancer through Synergistic Chemotherapy, Gene Therapy, and Photodynamic Therapy. ACS Appl. Mater. Interf. 2024, 49, 67203.

(7) Wu C.-Y.; Zhang X.; Zhang T.-Y.; Lu Z.-L.*, Transition-metal-free and solvent-tolerant decarboxylative iodination of aromatic carboxylic acids. Synth. Commun. 2024, 1, 84.

(8) Wu C.-Y.; Gao Y.-N.; Zhang X.; Zhang Z.-H.; Liu R.; Tang Q.*; Lu Z.-L.*,Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages. Chin. Chem. Lett., 2024, 11, 109649.

(9) Wang Q.; Xu D.-Z.; Zhang Z.-H.; Zhang X.; Liu R.; Lu Z.-L.*; Zhang C.-Y.*, GFP chromophore derived amphiphiles containing [12]aneN₃ and biotin moieties as bio-imaging and targeting nonviral gene vectors. J. Photoch. Photobio. A, 2024, 454, 115730.

(10) Zhang X.; Xu D.-Z.; Zhang Z.-H.; Ren Z.-X.; Wu .J.-R.; Xu Y.-J.; Lu Z.-L.*; Liu R.*; Liu Y.*, Functionalized polyesters based on valerolactones and [12]aneN₃ as effective non-viral gene vectors in HepG2 cells, Polym. Chem., 2024, 34, 3480.

(11) Sun X.-Y.; Zhang X.; Gao K.; Zhao W.-J.; Tian Y.-T. ; Liu T. ;Lu Z.-L.*, A mitochondria-specific NIR fluorescence probe for dual-detection of sulfur dioxide and viscosity in living cells and mice, Anal. Methods, 2024, 24, 3839.

(12) Liang Y.-X.; Sun X.-Y.; Xu D.-Z.; Gao Y.-N.; ;Tang Q.*; Lu Z.-L.*; ;Liu Y.*, Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN₃-Derived Lipid for Synergistic Lung Cancer Therapy, ACS Appl. Bio Mater., 2024, 5, 3202.

(13) Wu C.-Y.; Su S.; Zhang X.; Liu R.*; Gong B.; Lu Z.-L.*, Covalently linked hexakis(m-phenylene ethynylene) macrocycles as molecular nanotubes. Angew. Chem., Int. Ed., 2023, 62, e202303242.

(14) Sun X.-Y.; Liang Y.-X.; Gao Y.-N.; Zhang X.; Liu R.; Tang Q.*; Lu Z.-L.*; Liu Y.*, [12]aneN₃-Modified camptothecin and PEGylated AIEgens co-assembly into core-shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy. J. Mater. Chem. B., 2023, 11, 8943-8955.

(15) 王倩, 刘旭英, 唐芳, 卢忠林*. 基于大环多胺[12]aneN₃多功能非病毒基因载体的合成及性质. 科学通报, 2022, 67, 2298–2317.

(16) Liu X.-Y.; Zhang X.; Yang J.-B.; Wu C.-Y.; Wang Q.; Lu Z.-L.*; Tang Q., Multifunctional amphiphilic peptide dendrimer as nonviral gene vectors for effective cancer therapy via combined gene/photodynamic therapies. Colloids and Surfaces, B: Biointerfaces, 2022, 217, 112651.

(17) Liu X.-Y.; Yang J.-B.; Wu C.-Y.; Tang Q.; Lu Z.-L.*; Lin L.*; [12]aneN₃- Conjugated AIEgens with two-photon imaging properties for synergistic gene/photodynamic therapy in vitro and in vivo. J. Mater. Chem. B., 2022, 10, 945-957.

(18) Liang Y.-X.; Sun X.-Y.; Xu D.-Z.; Huang J.-R.; Tang Q.; Lu Z.-L.*; Liu R.*; H₂O₂-Responsive amphiphilic polymer with aggregation-induced emission (AIE) for DOX delivery and tumor therapy. Biorg. Chem., 2022, 119, 105559.

(19) Liu M.-X.; Liu X.-Y.; Liu J.-Y.; Tang J.-T.; Shi K.; Mao J.; Lu Z.-L.*; Qiao H.-J.*; He L.*; Di[12]aneN₃-functionalized green fluorescent protein chromophore for GFP luminescence simulation and efficient gene transfection in vitro and in vivo. ACS Appl. Bio. Mater., 2021, 4, 7111-7112.

(20) Ma L.-L.; Tang Q.; Liu M.-X.; Liu X.-Y.; Liu J.-Y.; Lu Z.-L.*; Gao Y.-G.; Wang R. [12]aneN₃-Based Gemini-Type Amphiphiles with Two-Photon Absorption Properties for Enhanced Nonviral Gene Delivery and Bioimaging. ACS Appl. Mater. Interf. ,2020, 12, 40094-40107.

(21) Wang Q.-H; Zhong Y.-L.; Miller D. P.; Lu X.-L.; Tang Q.; Lu Z.-L.; Zurek E.; Gong B.*; Liu R.* Self-assembly and molecular recognition in water: Tubular stacking and guest-templated discrete assembly of water-soluble, shape- persistent macrocycles. J. Am. Chem. Soc., 2020, 142, 2915-2924.

(22) Tang Q.; Zhong Y. -L.; Miller D. P.; Liu R.; Zurek E.; Lu Z-L.*; Gong B.* Reverse turn foldamers: An expanded β-turn motif reinforced by double hydrogen bonds. Org. Lett., 2020, 22, 1003-1007.

(23) Shi Y.-D.; Tang Q.; Jiang Y.-F.; Pei Q.; Tan H.-W.; Lu Z.-L.*; Gong B.*, Effective formation of stable and versatile double-stranded β-sheets templated by a hydrogen-bonded duplex. Chem. Comm., 2018, 54, 3719-3722.

(24) Li Z.-H.; Tan Z.-L.; Ding. A-X.; Gong B.; Lu Z.-L.*; He L.*, Nitric oxide-responsive vesicles as a drug delivery system. Chem. Commun., 2017, 53, 3535-38.

(25) Wang Q.-H.; Yu L.-J.; Liu Y.; Lin L.; Lu R.-G.; Zhu J.-P.; He L.*; Lu Z.-L.*， Methods for the detection and determination of nitrite and nitrate: A review. Talanta, 2017, 165, 709-20.

(26) Wei X.; Zhang G.; Shen Y.; Zhong Y.; Liu R.; Yang N.; Al-mkhaizim F. Y.; Kline M. A.; He L.; Li M.; Lu Z.-L.*; Shao Z.*; Gong B.*, Persistent organic nanopores amenable to structural and functional tuning. J. Am. Chem. Soc., 2016, 138, 2749-2754.

(27) Gao Y. G.; Shi Y. D.; Zhang Y.; Hu J.; Lu Z.-L.*; He L.* A naphthalimide-based [12]aneN₃ compound as an effective and real-time fluorescence tracking nonvival gene vector. Chem. Commun., 2015, 51, 16695-16698.

(28) Chen H.-L.; Guo Z.-F.; Lu Z.-L.* Controlling ion-sensing specificity of N-amidothioureas: From anion-selective sensors to highly Zn²⁺-selective sensors by tuning electronic effects. Org. Lett. 2012, 14, 5070-5073.

(29) Bunn S.-E.; Liu C.-T.; Lu Z.-L.*; Neverov A.-A.; Brown R.-S., Dinuclear Zn(II) complex catalyzed cyclization of a series of 2-hydroxypropyl aryl phosphate RNA models. Progressive change in mechanism from rate-limiting P-O bond cleavage to substrate binding. J. Am. Chem. Soc., 2007, 129, 11642-11652.

(30) Lu Z.-L.; Liu T.; Neverov A.-A.; Brown R.-S.; Rapid three-step cleavage of RNA and DNA model systems promoted by a dinuclear Cu(II)-complex in Methanol. Energetic origins of the catalytic efficacy, J. Am. Chem., Soc., 2007, 129, 11642-11652.

(31) Neverov, A.-A.; Lu Z.-L.; Maxwell, C.-I.; Mohamed, M.-F.; White, C.-J.; Tsang, J.-S.-W.; Brown, R.-S.; Combination of a dinuclear Zn²⁺ complex and a medium effect exerts a 10¹²-fold rate enhancement of cleavage of an RNA and DNA model system. J. Am. Chem. Soc., 2006, 128, ;16398-16405.

(32) Novak, F., Speiser B., Lindner E., Lu Z.-L., Mayer A., A chemically modified platinium electrod as a bidental diamine ligand forming well defined, immobilized bis(1-P-ether-phosphine)(diamine)ruthenium(II) complexes, Angew. Chem Int. Eng., 2004, e2256.

(33) Lu Z.-L.; Lindner E.; Mayer H.-A., Applications of sol-gel processed interphase catalysts. Chem. Rev., 2002, 102, 3543-3578.

(34) Lu Z.-L.; Duan C.-Y.; Tian Y.-P.; You X.-Z.; Huang X.-Y., Synthesis, characterization, and crystal structure of a novel copper(II) complex with an asymmetric coordinated 2,2'-bipyridine derivative: A model for the associative complex in the ligand-substitution reactions of [Cu(Tren)L]²⁺. Inorg. Chem., 1996, 35, 2253-2258.