樊新元 教授，Prof. Xinyuan Fan

    先后就读于兰州大学生物专业本科硕士、西班牙加泰罗尼亚化学研究所博士，历任北京大学博士后，南京工业大学教师，北京大学副研究员等，2026年起任北京师范大学化学学院/高等研究院教授。曾获国家优青、美国化学会Bioconjugate Chemistry Young Investigator Award、中国化学会光化学青年创新奖、勃林格殷格翰青年研究员奖、黄廷方信和杰出青年学者等，任中国化学会化学生物学学科委员会秘书长、中国生物化学与分子生物学会蛋白质组学专业分会委员，Chin Chem Lett编委、新兴科学和技术趋势期刊青年编委等。主持国家基金委专项研究项目、优青、重大研究计划培育、北京市重点等项目。

地址：北京市海淀区新街口外大街19号，北京师范大学化学学院，北京100875

邮箱：xyfan@bnu.edu.cn

课题组网页：https://www.x-mol.com/groups/xinyuanfan

招聘博士后、博士、硕士、联合培养学生、科研助理等职位，欢迎邮件联系！

研究兴趣和方向：

化学生物学，生物正交反应，生物正交光催化，邻近标记，光催化化学，时空组学，可控激活

长期致力于发展面向生命体系的前沿化学工具，聚焦于在难以基因操作的样品 (如原代细胞、组织及临床样品)中实现高效、精准的原位时空标记与调控。基于对生物正交反应与光催化化学的研究积累，提出生物正交光催化，以光催化剂进行空间靶向、以外源光提供时间分辨，开发了时空灵活可控的新型时空标记和调控技术。据此系统构建了一系列具代表性的光催化技术体系(CAT-X)，包括CAT-Prox (线粒体)、CAT-S (升级版)、CAT-Ex (膜受体)、CAT-Cell (胞际互作)、CAT-Tissue (组织)、CAT-Lyso (溶酶体)、CAT-ER (内质网)、CAT-seq (转录组)、CAT-ortho (多组学)、CAT-NIR (近红外)等，为时空组学研究、临床标志物发现、精准诊疗、活体遥控等研究提供了全新的化学策略。

代表性论文

35) Guo, H.#; Liu, Z.#; Guo, F.; Lou, Z.; Chen, P.*; Fan, X.*, “Enabling Proteins with Photocatalytic Functions via HisTag–Iridium Coordination.” J. Am. Chem. Soc. 2026, 148 (1), 1538–1551 (CAT-tag technology)

34) Qin, S.; Liang, X.; Chen, P.*; Fan, X.*, “Remote Molecule Activation in Living Mice Triggered by Therapeutic Ultrasound” Angew. Chem. Int. Ed. 2026, 65 (13), e25894 (dBus technology).

33) Y. Zhu; S. Liu; S. Qin; X. Wang; X. Zhang; Y. Shan; Fan, X.*, Chen, P.*, “Bioorthogonal Phenylalanine Decaging on Living Cells” Nat. Chem. 2026, accepted.

32) Guo, H.; Fan, X.*, Photocatalytic proximity labeling in primary samples. Curr. Opin. Chem. Biol. 2026, 92, 102678 (Invited review).

31) Zhou, N.; Zhang, Y.*; Fan, X.*, 溶酶体蛋白质组学研究的技术进展, 中国科学 生命科学 2026, DOI: 10.1360/SSV-2025-0357 (Invited review).

30) Bi, Y.#; Yu, L.#; Deng, Q.#; Kong, L.; Guo, F.; Zhang, Y.; Wang, R.; Chen, P.*; Liu, J.*; Fan, X.*, “Photocatalytic Proximity Labeling-Enabled Subcellular-Resolved RNA Profiling and Synchronous Multi-omics Investigation.” Nat. Chem. 2025, 17 (12), 1871-1882. (CAT-seq and CAT-ortho technologies)

Bi, Y.; Fan, X.*, “Simultaneous subcellular RNA–protein profiling with photocatalytic labelling.” Nat. Chem. 2025, 17 (12), 1817-1818. (Research Briefing of CAT-ortho)

29) Zhou, N.#; Zhang, Y.#; Chen, P.*; Fan, X.*, “Time-Resolved Photocatalytic Proximity Labeling Uncovers ER Proteome Dynamics Underlying UPR to Apoptosis Transition.” PNAS 2025, 122, e2503115122. (CAT-ER technology)

28) Lou, Z.#; Zhang, Y.#; Liang, X.; Cao, M.; Ma, Y.; Chen, P.*; Fan, X.*, “Deep-Red and Ultrafast Photocatalytic Proximity Labeling Empowered in situ Dissection of Tumor-Immune Interactions in Primary Tissues.” J. Am. Chem. Soc. 2025, 9716-9726. (CAT-Tissue technology)

27) Zhang, Y.#; Liu, Z.#; Zhou, N.#; Guo, F.; Guo, H.; Chen, X.; Chen, P.*; Fan, X.*, “In situ Lysosomal Proteomics Enabled by Bioorthogonal Photocatalytic Proximity Labeling.” Nat. Catal. 2025, 162-177 (CAT-Lyso technology)

26) Zhong, J.; Li, Y.; Li, X.; Liang, F.; Tao, R.; Qian, S.*; Fan, X.*, Near Infrared Light-Triggered Small Molecule Chemical Reactions in Biocompatible Systems. Bioconjugate Chem. 2025, 36 (7), 1362-1376.

25) Liu, Z.; Zhang, Y.; Fan, X.*; Chen, P. R.*, “Chemical Decoding of Spatial Biology”. Nat. Chem. Biol. 2025, 21 (7), 983-984.

24) Zhu, Y.; Lin, F.; Liu, Z.; Wang, X.; Wang, S.; Fan, X.*; Chen, P. R.*, “Bioorthogonal Cleavage Chemistry: Harnessing the Bond-Break Reactions for Biomolecule Manipulations in Living Systems”. Chin. J. Chem. 2025, 43 (5), 553-566.

23) Guo, F.; Sun, Z.; Ding, B.*; Fan, X.*, 第一过渡周期金属参与的光催化反应研究进展, 新兴科学和技术趋势 2025, 4 (2), 129-145.

22) Liu, Z.#; Guo, F.#; Zhu, Y.; Qin, S.; Hou, Y.; Lin, F.; Guo, H.; Chen, P.*; Fan, X.*, “Bioorthogonal Photocatalytic Proximity Labeling in Primary Living Samples.” Nat. Commun. 2024, 15 (1), 2712. (CAT-S technology)

21) Zhu, Y.#; Ding, W.#; Chen, Y.; Shan, Y.; Liu, C.; Fan, X.*; Lin, S.*; Chen, P.*, Genetically encoded bioorthogonal tryptophan decaging in living cells. Nat. Chem. 2024, 16 (4), 533-542

20) Zhang, Y.; Liu, S.; Guo, F.; Qin, S.; Zhou, N.; Fan, X.*; Chen, P.*, Bioorthogonal photocatalytic quinone methide decaging for cell-cell interaction labeling. J. Am. Chem. Soc. 2024, 146, 15186-15197. (CAT-Cell technology)

19) Guo, F.#; Zhu, J.#; Fan, X.*, Dual Role Tertiary Amines in Photocatalytic Cyclizations: Towards Sustainable Syntheses of 1,3-Dinitrogen Heterocycles. Chem. Commun. 2024, 60 (74), 10164-10167 (Invited paper for special issue “2024 emerging investigators”).

18) Guo, F.#; Qin, S.#; Liu, Z.#; Chen, P.*; Fan, X.*, Decaging-to-labeling: Development and investigation of quinone methide warhead for protein labeling. Bioorg. Chem. 2024, 143, 107088. (Invited paper for special issue “emerging investigators in chemical biology in China”).

17) Liang, X.#; Qian, S.#; Lou, Z.; Hu, R.; Hou, Y.; Chen, P.*; Fan, X.*, Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice. Angew. Chem. Int. Ed. 2023, e202310920. (CAT-NIR technology)

16) Zhang, X.#; Huang, H.#; Liu, Y.; Wu, Z.; Wang, F.; Fan, X.*; Chen, P.*; Wang, J.*, Optical Control of Protein Functions via Genetically Encoded Photocaged Aspartic Acids. J. Am. Chem. Soc. 2023, 145, 19218–19224.

15) Guo, F.#; Shan, S.#; Gong, X.#; Dai, C.; Quan, Z.*; Cheng, X.*; Fan, X.*, Deuteration Degree-Controllable Methylation via a Cascade Assembly Strategy using Methylamine-Water as Methyl Source. Chem. Eur. J. 2023, e202301458.

14) Liu, Y.; Ge, Y.; Zeng, R.; Ngai William Shu, C.; Fan, X.*; Chen, P.*, Proximity Chemistry in Living Systems. CCS Chem. 2023, 5, 802-813.

13) Fan, X.*; Chen, P.*, Deciphering Life Sciences with “Live” Chemistry—The 2022 Nobel Prize in Chemistry. Sci. China Chem. 2023, 66 (1), 7-9.

12) Liu, Z.; Xie, X.; Huang, Z.; Lin, F.; Liu, S.; Chen, Z.; Qin, S.; Fan, X.*; Chen, P.*, Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging. Chem 2022, 8, 2179–2191. (CAT-Ex technology)

11) Ngai, W. S. C.#; Yang, S.#; Zeng, X.; Liu, Y.; Lin, F.; Wang, X.; Zhang, H.; Fan, X.*; Chen, P.*, Bioorthogonally Activatable Base Editing for On-Demand Pyroptosis. J. Am. Chem. Soc. 2022, 144 (12), 5411-5417.

10) Luo, H.#; Tang, W.#; Liu, H.; Zeng, X.; Ngai, W. S. C.; Gao, R.; Li, H.; Li, R.; Zheng, H.; Guo, J.; Qin, F.; Wang, G.; Li, K.; Fan, X.*; Zou, P.*; Chen, P.*, Photocatalytic Chemical Crosslinking for Profiling RNA–Protein Interactions in Living Cells. Angew. Chem. Int. Ed. 2022, 61 (27), e202202008. (CAX technology)

9) Huang, Z.#; Liu, Z.#; Xie, X.; Zeng, R.; Chen, Z.; Kong, L.; Fan, X.*; Chen, P.*, Bioorthogonal Photocatalytic Decaging-Enabled Mitochondrial Proteomics. J. Am. Chem. Soc. 2021, 143 (44), 18714-18720. (CAT-Prox technology)

8) Wang J.#; Wang X.#; Fan, X.*; Chen P.*, Unleashing the Power of Bond Cleavage Chemistry in Living Systems. ACS Cent. Sci. 2021 7 (6), 929-943.

7) Zhu, J.#; Dai, C.#; Ma, M.; Yue, Y.; Fan, X.*, Visible light-mediated cross-coupling of electrophiles: synthesis of α-amino amides from isocyanates and ketimines. Org. Chem. Front. 2021, 8 (6): 1227-32.

6) Lizandara-Pueyo, C.*; Fan, X.*; Ayats, C.; Pericàs, M. A., Calcium carbonate as heterogeneous support for recyclable organocatalysts. J. Catal. 2021, 393, 107-115.

5) Wang, X.; Zhang, X.; Huang, Z.; Fan, X.*; Chen, P.*, Recent Progress of Bioorthogonal Chemistry in China. Acta Chim. Sinica 2021, 79 (4), 406-413.

4) Zhang, X.; Luo, H.; Fan, X.*; Chen, P.*, Development and applications of inverse-electron-demand Diels-Alder reaction in bioorthogonal chemistry. Sci. Sin. Chim. 2020, 50 (10), 1280-1295.

3) Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Reductive Cross-Coupling of Aldehydes and Imines Mediated by Visible Light Photoredox Catalysis”, Org. Lett. 2019, 21 (1), 27-31.

2) Fan, X.*; Gong, X.; Ma, M.; Wang, R.; Walsh, P. J.* “Visible Light-Promoted CO2 Fixation with Imines to Synthesize Diaryl α-Amino Acids”, Nat. Commun. 2018, 9(1), 4936.

1) Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Visible Light-Mediated Umpolung Reactivity of Imines: Ketimine Reductions with Cy2NMe and Water”, Org. Lett. 2018, 2433.