讲授课程

本科生：有机化学IIA（双语）、化学综合设计实验、普通化学

研究生：合成实验、高等有机合成

研究兴趣

生物有机化学：（1）具有生物活性的复杂糖缀合物的全合成；（2）新型荧光探针分子的合成与应用；（3）酶催化反应与酶的高效检测

代表性论文

1. Gai-li Feng, Yi-chen Liu, Yan-ming Ji, Wei Zhou, Xia-fen Li, Min Hou, Jie-lei Gao, Yuan Zhang, Guo-wen Xing* Water-soluble AIE-active fluorescent organic nanoparticles for ratiometric detection of SO₂ in the mitochondria of living cells Chem. Commun. 2022, 58, 6618-6621.

2. Wei Zhou, Yi-chen Liu, Guang-jian Liu, Xiao-xiao Niu, Xin Niu, Xia-fen Li , Gai-li Feng, Yuan Zhang*, Guo-wen Xing* Water-soluble meso-ester substituted BODIPY with aggregation-induced emission property for ratiometric detection of carboxylesterases in living hepatoma cell Dyes Pigm. 2022, 201, 110189.

3. Yan-ming Ji, Wenyan Zhang, Jing-dong Zhang, Xia-fen Li, Fan-dong Yu, Cui-yun Li, Guang-jian Liu, Guo-wen Xing*, Dual functional amphiphilic sugar-coated AIE-active fluorescent organic nanoparticles for the monitoring and inhibition of insulin amyloid fibrillation based on carbohydrate–protein interactions J. Mater. Chem. B, 2022, 10, 5602-5611.

4. Yi-chen Liu , Yuan Zhang, Guang-jian Liu, Guo-wen Xing* J- and H-aggregates of heavy-atom-free Aza-BODIPY dyes with high ¹O₂ generation efficiency and photodynamic therapy potential Dyes Pigm. 2022, 208, 110813.

5. Xia-fen Li, Wei Zhou, Yi-chen Liu, Min Hou, Gai-li Feng, Yan-ming Ji, Yuan Zhang*, Guo-wen Xing* Design and assembly of AIE-active fluorescent organic nanoparticles for anti-counterfeiting fluorescent hydrogels and inks. Chem. Commun. 2022, 58, 11547-11550.

6. Yi-chen Liu, Guang-jian Liu, Wei Zhou, Gai-li Feng, Qing-yu Ma, Yuan Zhang, Guo-wen Xing* In Situ Self-Assembled J-Aggregate Nanofibers of Glycosylated Aza-BODIPY for Synergetic Cell Membrane Disruption and Type I Photodynamic Therapy Angew. Chem. Int. Ed. 2023, 62, e202309786.

7. Jing-dong Zhang, Xiao-jie Gao, Si-cong Liu, Zhu-feng Geng, Le Chang, Yi-jiang Liu, Qing-yu Ma, Guo-wen Xing,* Guang-jian Liu,* De-cai Fang* α‑Stereoselective 3‑Deoxy‑D-manno-oct-2-ulosonoic Acid (Kdo) O‑Glycosylation with a p‑Toluenethioglycoside Donor by the (p‑Tol)₂SO/Tf₂O Preactivation Strategy Org. Lett. 2023, 25, 4150-4155.

8. Qing-yu Ma, Xiang Li, Wei Zhou, Xia-fen Li, Yi-chen Liu, Gai-li Feng, Hongwei Tan, Yuan Zhang*, Guo-wen Xing* A water-soluble fluorescent organic nano-photosensitizer for the ratiometric detection of mitochondrial G-quadruplexes with photodynamic therapy potential Chem. Commun. 2023, 59, 10287-10290.

9. Wei Zhou, Yi-chen Liu, Qing-yu Ma, Gai-li Feng, Jia-wei Zhang, Guang-jian Liu, Yuan Zhang, Guo-wen Xing* AIE-active lysosome-targeted fluorescent organic nanoparticles for leucine aminopeptidase-activatable fluorescent imaging and precision photodynamic therapy potential Dyes Pigm. 2024, 221, 111781.

10. Guang-jian Liu, Jing-dong Zhang, Wei Zhou, Gai-li Feng, Guo-wen Xing* Recent advances in sugar-based AIE luminogens and their applications in sensing and imaging Chem. Commun. 2024, 60, 11899-11915.

11. Wei Zhou, Yi-chen Liu, Guang-jian Liu, Yuan Zhang, Gai-li Feng, Guo-wen Xing* Glycosylated AIE-active Red Light-triggered Photocage with Precisely Tumor Targeting Capability for Synergistic Type I Photodynamic Therapy and CPT Chemotherapy Angew. Chem. Int. Ed. 2025, 64, e202413350.

12. Gai-Li Feng, Wei Zhou, Jin-ping Qiao, Guang-Jian Liu, Guo-Wen Xing* A glycosylated AIE-active Fe(III) photosensitizer activated by the tumor microenvironment for synergistic type I photodynamic and chemodynamic therapy Nanoscale, 2025, 17, 418-427.

13. Jing-dong Zhang, Guang-jian Liu, Guo-wen Xing* b-Stereoselective Kdo C-glycosylation by a (p-Tol)₂SO/Tf₂O preactivation strategy Chem. Commun. 2025, 61, 1677-1680.

14. Jia-wei Zhang, Gai-li Feng, Xin Niu, Yi-chen Liu, Wei Zhou, Qing-yu Ma, Guang-jian Liu, Yuan Zhang*, Guo-wen Xing* Glycosylated and rhodamine-conjugated tetraphenylethylene: a type I and II reactive oxygen species generator for photodynamic therapy Chem. Commun. 2025, 61, 3403-3406.

15. Yi-chen Liu, Gai-li Feng, Jia-long Jie, Wei Zhou, Guang-jian Liu, Yuan Zhang, Hong-mei Su, Guo-wen Xing* Hepatoma Metastasis-Inhibiting Supramolecular Nanoglycocalyx for Enhanced Type I Photodynamic Therapy Adv. Healthcare. Mater. 2025, 14, 2404253.