研究兴趣

  不对称催化、天然产物全合成、药物化学

招生信息

  每年招收博士生1名，硕士生1-2名。 

  欢迎热爱科研、工作认真、积极向上的同学加入。

  研究背景要求：有机合成化学或药物化学。

代表性论文

1. Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu*, Changgui Zhao*, Enantio-, Atrop-, and Diastereoselective Macrolactonization to Access Type III Cyclophanes. Nat. Commun. 2025, 16, 3170.

2. Hongxuan Zhai, Kang Lv, Jiayan Li, Jiaming Wang, Tao Liu*, Changgui Zhao*, Rhodium(III)-catalyzed Atroposelective Indolization to Access Planar-chiral Macrocycles, J. Am. Chem. Soc. 2024, 146, 29214–29223.

3. Jiayan Li, Ziyang Dong, Yang Chen, Zhanhui Yang, Xinen Yan, Meng Wang, Chenyang Li*, Changgui Zhao*. N-heterocyclic Carbene-catalyzed Enantioselective Synthesis of Planar-chiral Cyclophanes via Dynamic Kinetic Resolution. Nat. Commun. 2024, 15, 2338.

4. Jiaming Wang, Meng Wang, Yilu Wen, Peng Teng, Chenyang Li*, Changgui Zhao*. N-Heterocyclic Carbene-catalyzed Highly Enantioselective Macrolactonization to Access Planar-chiral Macrocycles. Org. Lett. 2024, 26, 1040.

5. Ziyang Dong, Jia Li, Ting Yao, Changgui Zhao*. Palladium-catalyzed Enantioselective C−H Olefination to Access Planar-chiral Cyclophanes by Dynamic Kinetic Resolution. Angew. Chem. Int. Ed. 2023, 62, e202315603.

6. Jiayan, Li, Changgui Zhao*. Highly Enantioselective Synthesis of Planar-chiral Cyclophanes through a Brønsted Acid-catalyzed Asymmetric Transfer Hydrogenation. ACS Catal. 2023, 13, 14155.

7. Ting Yao; Jia Li; Changgui Zhao*. N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of N-Fused Polycyclic Dihydropyrido[1,2-α]-indolones. Org. Lett. 2023, 25, 5061.

8. Ting Yao, Jia Li, Chengming Jiang, Changgui Zhao*. Recent Advances for the Catalytic Asymmetric Construction of Medium-Sized Rings. Chem Catal. 2022, 2, 2929.

9. Jiaming Wang, Changgui Zhao*, Jian Wang*. Recent Progress toward the Construction of Axially Chiral Molecules Catalyzed by an N-heterocyclic Carbene. ACS Catal. 2021, 11, 12520.

10. Changgui Zhao, Zhengqing Ye, Zhi-xiong Ma, Scott A. Wildman, Stephaine A. Blaszczyk, Lihong Hu, Ilia A. Guizei, Weiping Tang*. A Diversification Strategy for the Synthesis of Polycyclic Scaffolds with Medium Sized Rings from Complex Natural Products. Nat. Commun. 2019, 10, 4015.

11. Changgui Zhao, Daniel A. Glazier, Daoshan Yang, Dan Yin, Ilia A. Guizei, Michael M. Aristov, Peng Liu*, Weiping Tang*. Intermolecular Regio- and Stereoselective hetero-[5+2] Cycloaddition between Oxidopyrylium Ylides and Cyclic Imines. Angew. Chem. Int. Ed. 2019, 58, 887.

12. Changgui Zhao, Donghui Guo, Kristin Munkerup, Kuo-Wei Huang, Fangyi Li, Jian Wang*. Enantioselective [3+3] Atroposelective Annulation Catalyzed by N-heterocyclic Carbenes. Nat. Commun. 2018, 9, 611.

13. Changgui Zhao, Xingang Xie, Shuangshuang Duan, Huilin Li, Ran Fang, Xuegong She*. Gold-Catalyzed 1,2-Acyloxy Migration/Intramolecular [3+2] 1,3-Dipolar Cycloaddtion Cascade Reaction: An Efficient Strategy for Syntheses of Medium-Sized-Ring Ethers and Amines. Angew. Chem. Int. Ed. 2014, 53, 10789.

14. Changgui Zhao, Fangyi Li, Jian Wang*. N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones. Angew. Chem. Int. Ed. 2016, 55, 1820.